Aluminum Zirconium Trichlorohydrex Gly
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Aluminum Zirconium Trichlorohydrex Gly is a derivative of Aluminum Zirconium Trichlorohydrate in which some of the water molecules have been displaced by glycine, calcium glycinate, magnesium glycinate, potassium glycinate, sodium glycinate, or zinc glycinate. It encompasses a range of aluminum-to-zirconium atomic ratios between 2.0:1 and 5.99:1 and a range of (aluminum plus zirconium)-to-chloride atomic ratios between 2.1:1 and 1.51:1. It contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of anhydrous aluminum zirconium trichlorohydrate.
1 Packaging and storage
Preserve in well-closed containers.
2 Labeling
The label states the form of glycine used and the claimed content of anhydrous aluminum zirconium trichlorohydrate.
3 Identification
A: A solution (1 in 10) responds to the test for Chloride 〈191〉.
B: Place about 0.5 g of it in a 50-mL beaker, add about 20 mL of water, and swirl to dissolve. Heat to boiling on a hot plate, and add about 60mg of ninhydrin: a deep violet color immediately develops.
pH 〈791〉: between 3.0 and 5.0, in a solution [15 in 100 (w/w)].
Change to read:
Arsenic 〈211〉, Procedures, Procedure 1 (CN 1-Jun-2023) : 2 μg per g.
Limit of iron - Using Aluminum Zirconium Trichlorohydrex Gly instead of Aluminum Zirconium Octachlorohydrate, proceed as directed in the test for Limit of iron under Aluminum Zirconium Octachlorohydrate. The specified result is obtained (150 μg per g limit).
Content of aluminum - Using Aluminum Zirconium Trichlorohydrex Gly instead of Aluminum Zirconium Octachlorohydrate, proceed as directed in the test for Content of aluminum under Aluminum Zirconium Octachlorohydrate. Use the result obtained to calculate the Aluminum/zirconium atomic ratio and the (Aluminum plus zirconium)/chloride atomic ratio.
Content of zirconium - Using Aluminum Zirconium Trichlorohydrex Gly instead of Aluminum Zirconium Octachlorohydrate, proceed as directed in the test for Content of zirconium under Aluminum Zirconium Octachlorohydrate. Use the result obtained to calculate the Aluminum/zirconium atomic ratio and the (Aluminum plus zirconium)/chloride atomic ratio.
Aluminum/zirconium atomic ratio - Divide the percentage of aluminum found in the test for Content of aluminum by the percentage of zirconium found in the test for Content of zirconium, and multiply by 92.97/26.98, in which 92.97 is the atomic weight of zirconium corrected for 2% hafnium content, and 26.98 is the atomic weight of aluminum: the ratio is between 2.0:1 and 5.99:1.
Content of chloride - Using Aluminum Zirconium Trichlorohydrex Gly instead of Aluminum Zirconium Octachlorohydrate, proceed as directed in the test for Content of chloride under Aluminum Zirconium Octachlorohydrate. Use the result obtained to calculate the (Aluminum plus zirconium)/chloride atomic ratio.
(Aluminum plus zirconium)/chloride atomic ratio - Calculate the (aluminum plus zirconium)/chloride atomic ratio by the formula:
[(Al/26.98) + (Zr/92.97)]/(Cl/35.453)
in which Al, Zr, and Cl are the percentages of aluminum, zirconium, and chloride as determined in the tests for Content of aluminum, Content of zirconium, and Content of chloride, respectively; 26.98 is the atomic weight of aluminum; 92.97 is the atomic weight of zirconium corrected for 2% hafnium content; and 35.453 is the atomic weight of chlorine: the ratio is between 2.1:1 and 1.51:1.
Assay - Calculate the percentage of anhydrous aluminum zirconium trichlorohydrate in the Aluminum Zirconium Trichlorohydrex Gly by the formula:
Al({26.98y + 92.97 + 17.01[3y + 4 − (y + 1)/z] + 35.453(y + 1)/z}/26.98y)
in which Al is the percentage of aluminum found in the test for Content of aluminum, y is the aluminum/zirconium atomic ratio found in the test for Aluminum/zirconium atomic ratio, z is the (aluminum plus zirconium)/chloride atomic ratio found in the test for (Aluminum plus zirconium)/chloride atomic ratio, 26.98 is the atomic weight of aluminum, 92.97 is the atomic weight of zirconium corrected for 2% hafnium content, 17.01 is the molecular weight of the hydroxide anion (OH), and 35.453 is the atomic weight of chlorine (Cl).
