Aluminum Sulfate
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Change to read:
Al2(SO4)3·xH2O (ERR 1-Nov-2024)
Sulfuric acid, aluminum salt (3:2), hydrate.
Aluminum sulfate (2:3) hydrate CAS RN: 17927-65-0; UNII: 34S289N54E.
Anhydrous 342.13 (ERR 1-Nov-2024) CAS RN®: 10043-01-3; UNII: 17T908772F.
Aluminum Sulfate contains not less than 54.0 percent and not more than 59.0 percent of Al2(SO4)3. It contains a varying amount of water of crystallization.
1 Packaging and storage
Preserve in well-closed containers.
2 Identification
A solution (1 in 10) responds to the tests for Aluminum and for Sulfate (191).
3 PH (791)
Not less than 2.9, in a solution (1 in 20).
4 WATER DETERMINATION, Method I (921)
Not less than 41.0% and not more than 46.0%.
5 Limit of alkalies and alkaline earths
To a boiling solution of 1.0 g in 150 mL of water add a few drops of methyl red TS and then add 6 N ammonium hydroxide just until the color of the solution changes to a distinct yellow. Add hot water to restore the volume to 150 mL, and filter while hot. Evaporate 75 mL of the filtrate to dryness, and ignite to constant weight: not more than 2 mg of residue remains (0.4%).
6 Limit of ammonium salts
Heat 1 g with 10 mL of 1 N sodium hydroxide on a steam bath for 1 minute: the odor of ammonia is not perceptible.
7 Iron
To 20 mL of a solution (1 in 150) add 0.3 mL of potassium ferrocyanide TS: no blue color is produced immediately.
8 Assay
8.1 Edetate disodium titrant
Prepare and standardize as directed in the Assay under Ammonium Alum.
8.2 Procedure
Transfer about 7.5 g of Aluminum Sulfate, accurately weighed, to a 250-mL volumetric flask, and dissolve in water. Dilute with water to volume, mix, and pipet 10 mL of the solution into a 250-mL beaker. Proceed as directed in the Assay for aluminum oxide under Aluminum Acetate Topical Solution, beginning with "add, in the order named". Each mL of 0.05 M Edetate disodium titrant is equivalent to 8.554 mg of Al2(SO4)3.
