Acetic Acid, Glacial, TS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
—Determine the water content of a specimen of glacial acetic acid by the Titrimetric Method (see Water Determination〈921〉). If the acid contains more than 0.4% of water, add a few mL of acetic anhydride, mix, allow to stand overnight, and again determine the water content. If the acid contains less than 0.02% of water, add sufficient water to make the final concentration between 0.02% and 0.4%, mix, allow to stand
overnight, and again determine the water content. Repeat the adjustment with acetic anhydride or water, as necessary, until the resulting solution shows a water content of not more than 0.4%.
