4-Chlorobenzoic Acid
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
ClC6H4COOH 156.57 CAS RN: 74-11-3.—White, crystalline solid.
Assay: Dissolve about 700 mg, accurately weighed, in a mixture of 100 mL of hot alcohol and 50 mL of water. Titrate with 0.5 N sodium hydroxide VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.5 N sodium hydroxide is equivalent to 78.28 mg of ClC6H4COOH. Not less than 98% is found.
Solubility: One g dissolved in 25 mL of 0.5 N sodium hydroxide yields a clear and complete solution.
