2 N Acetic Acid VS

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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Transfer _{(USP 1-Aug-2020)} 116 mL of glacial acetic acid to a _{(USP 1-Aug-2020)} 1000-mL volumetric flask containing about 500 mL of water.

Cool and dilute with water to volume.

Standardization

See Volumetric Solutions, 1. Definitions.

See Titrimetry (541).

[NOTE-Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]

Accurately transfer 10 mL of the 2 N acetic acid solution to a beaker. Add 50 mL of carbon dioxide-free water. Titrate potentiometrically with 1 N sodium hydroxide VS.

N = (mL NaOH×N NaOH) / (mL acetic acid)

[Note—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.] _{(USP 1-Aug-2020)}