0.1 N Sodium Hydroxide VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(USP 1-May-2023)
Transfer 100 ml of 1 N sodium hydroxide VS to a 1000-ml volumetric flask. Dilute with carbon dioxide-free water to volume.
Standardization
A See Volumetric Solutions. 1. Introduction.
See Titrimetry (541).
Standardize by one of the following procedures. [NOTE-Other standardization procedures may be used. See Volumetric Solutions. 2. Preparation and Standardization. 2.3 Standardization.] (USP 1-May-2023)
Standardization with visual endpoint: (USP 1-May-2023) Accurately weigh about 500 mg of potassium biphthalate, previously crushed lightly and dried at 120° for 2 h, and dissolve in 75 mL of carbon dioxide-free water. Add 2 drops of phenolphthalein TS, and titrate with 0.1 N sodium hydroxide VS to the production of a permanent pink color. Each 20.422 mg of potassium biphthalate is equivalent to 1 mL of 0.1 N sodium hydroxide (USP 1-May-2023)
N = [g KHC8H4O4 × (Assay/100)] / (0.20422 × mL NaOH solution)
where Assay is the content/potency of potassium biphthalate.
Standardization with potentiometric endpoint: Accurately weigh about 200 mg of potassium biphthalate, previously crushed lightly and dried at 120° for 2 h, and dissolve in 100 mL of carbon dioxide-free water. Titrate with the sodium hydroxide solution using a combined pH electrode. Each 20.422 mg of potassium biphthalate is equivalent to 1 mL of 0.1 N sodium hydroxide.
N = [g KHC8H4O4 × (Assay/100)] / (0.20422 × mL NaOH solution)
where Assay is the content/potency of potassium biphthalate (USP 1-May-2023)
[NOTE-If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
