0.1 N Ceric Sulfate VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Use commercially available volumetric standard solution.
Standardization
See Volumetric Solutions, 1. Definitions.
See Titrimetry 〈541〉.
Standardize by one of the following procedures. [Note - Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
Standardization with visual endpoint: Accurately weigh about 0.2 g of sodium oxalate, primary standard, dried according to the label instructions or, if this information is not available, dried at 105° for 2 h, and dissolve in 75 mL of water. Add, with stirring, 2 mL of sulfuric acid that has previously been mixed with 5 mL of water, mix well, add 10 mL of hydrochloric acid, and heat to between 70° and 75°. Titrate with 0.1 N ceric sulfate to a permanent slight yellow color. Each 6.700 mg of sodium oxalate is equivalent to 1 mL of 0.1 N ceric sulfate.
N = (mg Na2C2O4 × (Assay/100)) / (67.00 × mL Ce(SO4)2 solution)
where Assay is the content/potency of sodium oxalate. (USP 1-May-2024)
Standardization with potentiometric endpoint: Accurately weigh about 0.1 g of sodium oxalate, primary standard, dried according to the label instructions or, if this information is not available, dried at 105° for 2 h, and dissolve in 75 mL of water. Add, with stirring, 1 mL of sulfuric acid that has previously been mixed with 2.5 mL of water, mix well, add 5 mL of hydrochloric acid, and heat to between 70° and 75°. Titrate potentiometrically with 0.1 N ceric sulfate using a combined platinum electrode.
N = (mg Na2C2O4 × (Assay/100)) / (67.00 × mL Ce(SO4)2 solution)where Assay is the content/potency of sodium oxalate. (USP 1-May-2024)
[Note - If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
