0.01 N Hydrochloric Acid VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Transfer 100 mL of 0.1 N hydrochloric acid VS to a 1000-mL volumetric flask. Dilute with water to volume.
Standardization:
See Volumetric Solutions, 1. Introduction.
See Titrimetry 〈541〉.
Standardize by one of the following procedures. [Note—Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
Standardization with visual endpoint: Accurately weigh about 25 mg of tromethamine, dried according to the label instructions or, if this information is not available, dried at 105° for 3 h. Dissolve in 50 mL of water and add 2 drops of bromocresol green TS. Titrate with the 0.01 N hydrochloric acid to a pale yellow endpoint. where Assay is the content/potency of tromethamine.
Standardization with potentiometric endpoint: Accurately weigh about 20 mg of tromethamine, dried according to the label instructions or, if this information is not available, dried at 105° for 3 h. Dissolve in 50 mL of water. Determine the endpoint potentiometrically, using a combined pH electrode. where Assay is the content/potency of tromethamine. (USP 1-Dec-2020)
[Note—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
