0.002 N Silver Nitrate in Isopropyl Alcohol VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(USP 1-Aug-2023)
Transfer 20.0 mL of 0.1 N silver nitrate VS to a 1000-mL volumetric flask, and dilute with isopropyl alcohol to volume. Store in a low-actinic flask.
Standardization
See Volumetric Solutions, 1. Introduction. See Titrimetry 〈541〉.
Standardize by one of the following procedures. [NOTE—Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
Standardization with visual endpoint: Transfer 0.20 mL of 0.1 N sodium chloride VS to a 150-mL beaker containing 50 mL of water, and add 50 mL of alcohol, 5 mL of acetic acid, and 0.5 mL of eosin Y TS. Stir, preferably with a magnetic stirrer, and titrate with the silver nitrate solution.
N = (mL NaCl × N NaCl) / (mL AgNO3)
Standardization with potentiometric endpoint: Transfer 0.20 mL of 0.1 N sodium chloride VS to a 150-mL beaker containing 50 mL of water, and add 50 mL of alcohol, 5 mL of acetic acid. Stir, preferably with a magnetic stirrer, and titrate with the silver nitrate solution using a combined silver electrode.
N = (mL NaCl × N NaCl) / (mL AgNO3)
[NOTE—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.] (USP 1-AUG-2023)
