0.002 M Edetate Disodium VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(USP 1-Aug-2024)
Transfer 20 mL of 0.1 M edetate disodium VS to a 1000-mL volumetric flask. Dilute with water to volume.
Standardization
See Volumetric Solutions, 1. Introduction. See Titrimetry 〈541〉.
Standardize by the following procedure. [NOTE—Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
Standardization with potentiometric endpoint: Accurately weigh about 100 mg of chelometric standard calcium carbonate, previously dried at 210° for 4 h and cooled in a desiccator, or dried according to the label instructions, transfer to a 500-mL volumetric flask, add 10 mL of water, and swirl to form a slurry. Introduce diluted hy drochloric acid from a pipet until the calcium carbonate is completely dissolved, then dilute with water to volume. Transfer 10.0 mL of the above calcium carbonate solution into a 200-mL beaker and dilute with water to about 100 mL. Add 5 mL of ammoniacal buffer, pH 10, and titrate potentiometrically with the edetate disodium solution using a combined calcium ion-selective electrode.
M = (g CaCO3)(1000)(Assay/100) × 0.02 / (100.09 × mL EDTA)
where Assay is the content/potency of calcium carbonate.
[NOTE—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
(USP 1-Aug-2024)
