0.5 N Hydrochloric Acid in Methanol VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
HCI, 36.46
18.23 g in 1000 mL
To a 1000-mL volumetric flask containing 40 mL of water slowly add 43 mL of hydrochloric acid. Cool, and add methanol to volume.
Standardization: Accurately weigh about 2.5 g of tromethamine, dried according to the label instructions or, if this information is not available, dried at 105° for 3 h. Dissolve in 50 mL of water and add 2 drops of bromocresol green TS. Titrate with 0.5 N hydrochloric acid in methanol to a pale yellow endpoint. Each 60.57 mg of tromethamine is equivalent to 1 mL of 0.5 N hydrochloric acid in methanol.
N= mg tromethamine/(121.14 x mL HCI)
[NOTE-If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
