0.1 N Perchloric Acid in Dioxane VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
HClO4, 100.46
10.05 g in 1000 mL
Mix 8.5 mL of perchloric acid with sufficient dioxane to make 1000 mL.
Standardization: Accurately weigh about 700 mg of potassium biphthalate, previously crushed lightly and dried at 120° for 2 h, and dissolve in 50 mL of glacial acetic acid in a 250-mL flask. Add 2 drops of crystal violet TS, and titrate with the perchloric acid solution until the violet color changes to bluish green. Carry out a blank determination. Each 20.422 mg of potassium biphthalate is equivalent to 1 mL of 0.1 N perchloricacid.
N= (g KHC8H4O4)/(0,20422 X mL HCLO4 solution(corected for the black))
[Note—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
