0.1 M Zinc Sulfate VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(USP 1-Dec-2022)
Dissolve 28.8 g of zinc sulfate heptahydrate in water to make 1 L.
1 Standardization
See Volumetric Solutions, 1. Introduction.
See Titrimetry (541).
Standardize by one of the following procedures. [NOTE-Other standardization procedures may be used. See Volumetric Solutions. 2. Preparation and Standardization, 2.3 Standardization.]
1.1 Standardization with visual end point
(USP 1-Dec-2022) Accurately measure about 10 mL of 0.1 M edetate disodium VS into a 125-mL
conical flask, and add, in the order given, 10 mL of acetic acid-ammonium acetate buffer TS, 50 mL of alcohol, and 2 mL of dithizone TS. Titrate with the zinc sulfate solution to a clear, rose-pink color.
M = (ml edetate disodium x M edetate disodium)/ml ZnSO4
(ERR 1-Dec-2022)
1.2 Standardization with potentiometric end point
Accurately measure about 10 mL of 0.1 M edetate disodium VS into a 125-mL conical flask, and add, in the order given, 10 mL of acetic acid-ammonium acetate buffer TS, 50 ml of alcohol, and 1 mL of Copper-EDTA.complex solution. Titrate with the zinc sulfate solution using a copper ion-selective electrode.
M = (ml edetate disodium x M edetate disodium)/ml ZnSO4
(ERR 1-Dec-2022)
[NOTE-If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
