0.05 M Barium Perchlorate VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Diluted acetic acid solution: Transfer 28.5 mL of glacial acetic acid to a 100-mL volumetric flask. Dilute with water to volume.
Diluted ammonia solution: Transfer 75 mL of stronger ammonia water to a 100-mL volumetric flask. Dilute with water to volume.
Buffer solution pH 3.7: Transfer 15.0 mL of Diluted acetic acid solution to a 100-mL volumetric flask. Add 60 mL of alcohol and 20 mL of water. Adjust with Diluted ammonia solution to a pH of 3.7. Dilute with water to volume.
(USP 1-Aug-2020)
Barium perchlorate solution: Dissolve 15.8 g of barium hydroxide in a mixture of 7.5 mL of perchloric acid and 75 mL of water. Adjust with perchloric acid to a pH of 3 and filter if necessary. Add 150 mL of alcohol and dilute with water to 250 mL. Dilute with Buffer solution pH 3.7 to 1000 mL.
1 Standardization
See Volumetric Solutions, 1. Definitions.
See Titrimetry 〈541〉.
Standardize by one of the following procedures.
[Note—Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
1.1 Standardization with visual endpoint
0.1 N sulfuric acid: Transfer 10 mL of 1 N sulfuric acid VS to a 100 mL volumetric flask and dilute to volume with water. (USP 1-Aug-2020)
To 5.0 mL of 0.1 N sulfuric acid (USP 1-Aug-2020) add 5 mL of water, 50 mL of Buffer solution pH 3.7, and 0.5 mL of sodium alizarinsulfonate TS. Titrate with the Barium perchlorate solution until an orange-red color appears. Standardize immediately before use.
M = (mL sulfuric acid × N sulfuric acid × 0.5)/ mL barium perchlorate
1.2 Standardization with potentiometric endpoint
Ammonia buffer solution pH 10: Transfer 54 g of ammonium chloride to a 1000 mL volumetric flask containing about 200 mL of water, swirl until dissolved. Add 350 mL of 25% ammonia water. Dilute to volume with water.
To 50 mL of water, add 10.0 mL of 0.05 M barium perchlorate solution, 5 mL of Ammonia buffer solution pH 10 and 1 mL of Copper–EDTA complex solution. Titrate potentiometrically with 0.05 M edetate disodium VS using a copper ion-selective electrode. Standardize immediately before use.
M = (mL edetate solution × N edetate solution)/ mL barium perchlorate (USP 1-Aug-2020)
[Note—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
