0.025 N Sodium Hydroxide VS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Transfer 25 mL of 1 N sodium hydroxide VS to a 1000-mL volumetric flask. Dilute with carbon dioxide-free water to volume.
Standardization
See Volumetric Solutions, 1. Introduction.
See Titrimetry 〈541〉.
Standardize by the following procedure.
[Note—Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.]
Standardization with potentiometric endpoint: (USP 1-May-2023)
Accurately weigh about (USP 1-May-2023) mg of potassium biphthalate, previously crushed lightly and dried at 120° for 2 h, and dissolve in 75 mL of carbon dioxide-free water. ▲Titrate with the sodium hydroxide solution using a combined pH electrode.▲ (USP 1-May-2023)
N ={g KHC₈H₄O₄ \times (Assay/100)}/{0.20422 \ mL NaOH solution}
where Assay is the content/potency of potassium biphthalate. (USP 1-May-2023)
[Note—If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]
