0.01 N Sulfuric Acid VS

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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H₂SO₄               98.08

0.4904 g in 1000 mL

Transfer 10 mL of 1 N sulfuric acid VS to a 1000-ml volumetric flask. Dilute with water to volume.

Standardization: Accurately weigh about 50 mg of tromethamine, dried according to the label instructions or, if this information is not available, dried at 105° for 3 h. Dissolve in 50 mL of water. Titrate with 0.01 N sulfuric acid solution. Determine the endpoint potentiometrically. Each 1.2114 mg of tromethamine is equivalent to 1 mL of 0.01 N sulfuric acid.

               N = (mg trometha min e)/ (121.14 x mL H₂SO₄)

[NOTE-If this volumetric solution is used in a qualitative application, such as pH adjustment, dissolution medium, or diluent, its standardization is not required.) _{▲(USP 1-MAY-2019)}