0.01 M Bismuth Nitrate VS

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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(USP 1-Aug-2020)

Dissolve 4.86 g of Bismuth nitrate pentahydrate in 60 mL of diluted nitric acid, and add 0.01 N nitric acid to make 1000 mL.

1 Standardization

See Volumetric Solutions, 1. Definitions.

See Titrimetry (541).

Standardize by one of the following procedures. (NOTE-Other standardization procedures may be used. See Volumetric Solutions, 2. Preparation and Standardization, 2.3 Standardization.)

1.1 Standardization with visual endpoint

(USP 1-Aug-2020) Accurately measure 25 mL of the prepared bismuth nitrate solution, add 50 mL of water and 1 drop of xylenol orange TS, and titrate the solution with 0.01 M edetate disodium VS until the red color changes to yellow.

M = (mL EDTA x M EDTA)/mL bismuth nitrate

1.2 Standardization with potentiometric endpoint

Acetate buffer, pH 4.7: Transfer 116 g of ammonium acetate to a 1000-mL volumetric flask containing about 200 mL of water, and swirl until dissolved. Add 86 mL of glacial acetic acid and dilute with water to volume.

Accurately measure 25 mL of the bismuth nitrate solution into a titration vessel, add 5 mL of Acetate buffer, pH 4.7 and 5 mL of 0.01 M edetate disodium VS. After a reaction time of 1 min, titrate potentiometrically with 0.1 N cupric nitrate VS using a copper ion-selective electrode.

M = [(mL EDTA x M EDTA) - (mL cupric nitrate x N cupric nitrate)]/mL bismuth nitrate

(USP 1-Aug-2020)

[NOTE-If this volumetric solution is used in a qualitative application such as pH adjustment, dissolution medium, or diluent, its standardization is not required.]